The health and well-being of transgender children and adolescents have been a growing concern in the fields of health and medicine as well as in public discourse and media. Only a decade ago, there was little scientific evidence regarding the health of transgender and gender-diverse (TGD) youth. Since then, media coverage has dramatically changed public awareness and understanding of TGD individuals, and this new public attention has disrupted the silence that had characterized the lives of TGD youth. At the same time, research has begun to clearly document the mental and behavioral health risks of TGD youth.